Alzheimer's link to cold sore bug

by Paul Conneally | December 7, 2008 at 11:35 pm
569 views | 32 Recommendations | 3 comments

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A discovery that could see some simple anti-viral drugs being used to help prevent Alzheimer's disease has been found.

The virus that causes cold sores has been found in plaques in the brains of people suffering with the Alzheimer's and although no direct causality has been found between getting cold sores and Alzheimer's the prospect of using anti-viral drugs to prevent the disease is a real prospect.

The cold sore virus is the herpes simplex virus (HSV-1) and is very similar to the genital herpes virus HSV-2 and both could be associated with the discovered brain plaques.

Scientists have discovered a link between the virus that causes cold sores and brain changes that occur with Alzheimer's disease. It is too early to say whether the virus causes the disease, but the researchers say it raises the possibility that standard anti-viral drugs could in future be used to treat the disease or prevent it from occurring.

The researchers have found that herpes simplex virus type 1 is found within so-called amyloid plaques in the brains of people who died of Alzheimer's, suggesting that it may have a role in causing the damage. According to the NHS, Alzheimer's is the most common form of dementia. It affects about 450,000 people. In over-65s, about one in 20 people are affected, rising to one in five over 80.

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Uwe Paschen

That is a new theory I haven't heard off yet. 

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Paul Conneally

Hi Paschen - I hadn't either and there is no causality shown yet only the observation that these plaques in the brains of patients suffering from Alzhiemer's have the herpes virus within them - there maybe other viral plaques present that haven't yet been 'looked for' or there may be really a causal link.


If the causal link is proved then anti-viral drugs may offer some scope for use.

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Uwe Paschen

According to some Estimates by the WHO close to 90% of the World population are carrier of this virus. 

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Uwe Paschen
First Flagged at 7:05 AM, Dec 8, 2008 by Uwe Paschen
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