Breast cancer gene-free baby born

The first baby in the UK tested before conception for a genetic form of breast cancer has been born.

Doctors at University College London said the girl and her mother were doing well following the birth this week.

The embryo was screened for the altered BRCA1 gene, which would have meant the girl had a 80% chance of developing breast cancer.

Women in three generations of her husband's family have been diagnosed with the disease in their 20s.

Paul Serhal, the fertility expert who treated the couple, said: "This little girl will not face the spectre of developing this genetic form of breast cancer or ovarian cancer in her adult life.

"The parents will have been spared the risk of inflicting this disease on their daughter.

"The lasting legacy is the eradication of the transmission of this form of cancer that has blighted these families for generations."

Pre-implantation genetic diagnosis (PGD) involves taking a cell from an embryo at the eight-cell stage of development, when it is around three-days old, and testing it.

This is before conception - defined as when the embryo is implanted in the womb.

Using PGD to ensure a baby does not carry an altered gene which would guarantee a baby would inherit a disease such as cystic fibrosis, is well-established.

But in 2006, the Human Fertilisation and Embryology Authority said doctors could test for so-called susceptibility genes, such as BRCA1.

Everybody carries a version of these genes - in fact a properly functioning BRCA1 protein helps stop cancer before it starts - but some particular variations of the genes greatly increase the risk of cancer.