Truemors
The activity of resveratrol, a component of red grapes and red wine, has for some time been associated with cholesterol-lowering benefits. Now it appears that researchers at the pharmaceutical giant Glaxo have not only identified the possible mechanism of resveratrol, but synthesized a drug that is 1000 times more powerful.
The drug, SIRT1720, controlled weight gain and endurance metabolism in rat studies. SIRT1720 may also serve as a prototype for another medication using the same mechanism for glucose control in diabetics.
The findings, published in the journal Cell Metabolism, show that mice fed a high-fat diet for 10 weeks who were given 100-milligram or 500-milligram doses of the med stayed svelte; animals on the same diet that didn't receive the drug packed on the pounds. The 10 medicated mice also ran twice as long as normal rodents.
The drug works by triggering a protein called SIRT1 that normally kicks in during starvation and tells the body to burn fat and conserve energy, according to the study.
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